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Updated: Jul 14, 2026
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Microsurgical Clip Obliteration of Middle Cerebral Aneurysm Using Intraoperative Flow Assessment
Published on: September 25, 2009
Multiple cerebral aneurysms in patients with sickle cell disease
1Department of Medicine, University of Tennessee, Memphis 38103.
Southern Medical Journal
|April 1, 1993
Summary
Patients with sickle cell disease (SCD) have a higher risk of cerebral aneurysms, unrelated to common risk factors. This study explores the link between SCD and brain aneurysms, proposing a potential formation mechanism.
Area of Science:
- Neurology
- Hematology
- Vascular Medicine
Background:
- Sickle cell disease (SCD) is a genetic blood disorder with various complications.
- Cerebral aneurysms are abnormal bulges in brain blood vessels.
- Traditional risk factors for aneurysms include hypertension and connective tissue disorders.
Observation:
- Patients with SCD exhibit a notably high incidence of cerebral aneurysms.
- These aneurysms in SCD patients often lack the typical associated risk factors.
- Two cases of SCD patients with multiple cerebral aneurysms are presented.
Findings:
- A strong association exists between sickle cell disease and the development of cerebral aneurysms.
- The pathogenesis of aneurysms in SCD may differ from conventional causes.
- A potential mechanism linking SCD to aneurysm formation is discussed.
Implications:
- Increased awareness and screening for cerebral aneurysms in sickle cell disease patients are warranted.
- Understanding the unique mechanism could lead to targeted preventative strategies.
- Further research into vascular complications of SCD is crucial for improved patient outcomes.
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