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A Murine Model of Group B Streptococcus Vaginal Colonization
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Published on: November 16, 2016

[Maternal deficiency of IgG 2 and IgG 4 and neonatal infection caused by B-streptococci]

B Maak1, E Müller, H Berbig

  • 1Kinderklinik, Thüringen-Klinik Georgius Agricola, Saalfeld GmbH.

Zentralblatt Fur Gynakologie
|January 1, 1993
PubMed

We describe here an newborn infant born in the 39th week of gestation with an early onset sepsis caused by group B streptococci. The intravenous administration of antibiotics and immunoglobulin preparation was unable to prevent the fatal outcome. The boy died after 16 hours of life. In the maternal serum a marked deficiency of IgG 2 and IgG 4 could be demonstrated. According to the results from the literature it seems possible that partial immunodeficiencies are important factors in the pathogenesis of the B-streptococcal disease of the newborn.

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