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Determination of thiol-containing drugs by chemiluminescence-flow injection analysis
P Viñas1, I Lopez Garcia, J A Martinez Gil
1Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, Spain.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1993
Abstract:
A flow injection analysis procedure with chemiluminescence detection for the determination of both thiol-containing drugs and the amino acid cysteine is described. Procedures are based on the inhibition by the drugs of the chemiluminescence generated in the copper-catalysed oxidation of luminol by hydrogen peroxide. The proposed methods were applied to the determination of cysteine, N-acetylcysteine, penicillamine, 2-mercaptopropionylglycine and thiouracil in pharmaceuticals.