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Related Experiment Videos

Uveal metastasis from prostate carcinoma

P De Potter1, C L Shields, J A Shields

  • 1Oncology Service, Wills Eye Hospital, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.

Cancer
|May 1, 1993
PubMed
Summary

Prostate carcinoma rarely metastasizes to the uvea, occurring in 2% of patients with uveal metastasis. Uveal metastasis from prostate cancer is linked to significantly shorter survival times.

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Area of Science:

  • Ophthalmology
  • Oncology

Background:

  • Breast and lung cancers are the most common causes of uveal metastasis.
  • Prostate carcinoma is a rare cause of metastatic tumors to the uvea.

Purpose of the Study:

  • To determine the frequency of prostate carcinoma as the primary neoplasm in patients with uveal metastasis.
  • To analyze the clinical characteristics and outcomes of patients with uveal metastasis from prostate cancer.

Main Methods:

  • Retrospective review of 379 consecutive patients with uveal metastasis.
  • Identification of patients with prostate carcinoma as the primary tumor.

Main Results:

  • Prostate carcinoma was the primary tumor in 7 patients (2% of all, 5% of male patients).

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  • The mean age at diagnosis was 66 years, with a known prior history in 85% of cases.
  • The choroid was the most common site of metastasis (85%), and survival was poor, with a mean of 6 months post-uveal metastasis diagnosis.

    • Conclusions:

    • Prostate carcinoma can metastasize to the uvea.
    • Uveal metastasis from prostate cancer is associated with a poorer prognosis and shorter survival compared to metastasis to other sites.