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A new pericentric inv(8) in acute nonlymphocytic leukemia
A Santoro1, P Carbone, F Caradonna
1Dipartimento di Ematologia, Ospedale V. Cervello, USL 60, Palermo, Italy.
Cancer Genetics and Cytogenetics
|March 1, 1993
Abstract:
Chromosome studies were carried out on unstimulated bone marrow cells from a patient with a diagnosis of acute nonlymphocytic leukemia (FAB M6 ANLL). Cytogenetic analysis revealed a mosaic chromosome pattern 46,XX/46,XX,inv(8)(p21q24). This pericentric inversion has not been previously described in ANLL. Because, fragile sites, zinc finger gene loci, and the MYC protooncogene have been localized to band 8q24, a putative role for these sites and genes could be considered.