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Persistent chorea after recurrent hypoglycemia. A case report

H Hefter1, P Mayer, R Benecke

  • 1Department of Neurology, University of Düsseldorf, FRG.

European Neurology
|January 1, 1993
PubMed
Summary
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Hypoglycemic comas in a 72-year-old woman led to the development of chorea, a movement disorder. This condition persisted for over a decade, despite intermittent worsening, highlighting a rare complication of diabetes mellitus.

Area of Science:

  • Neurology
  • Endocrinology
  • Movement Disorders

Background:

  • Diabetes mellitus is a chronic metabolic disorder with various complications.
  • Hypoglycemia, or low blood sugar, can have acute and severe neurological consequences.
  • Chorea is a hyperkinetic movement disorder characterized by involuntary, irregular, and purposeless movements.

Observation:

  • A 72-year-old woman developed bilateral chorea at age 58.
  • The onset of chorea followed a series of hypoglycemic coma episodes.
  • The choreiform movements persisted untreated for over 10 years, with intermittent exacerbations.

Findings:

  • The patient's neurological examination was otherwise normal, apart from the hyperkinetic movements.
  • Cranial computed tomography (CT) scan revealed no significant abnormalities.

Related Experiment Videos

  • This case suggests a potential link between severe hypoglycemia and the development of chorea in diabetic patients.

    • Implications:

    • This case highlights a rare neurological sequela of severe hypoglycemia in the context of long-standing diabetes mellitus.
    • Further research may elucidate the pathophysiological mechanisms connecting hypoglycemia and chorea.
    • Understanding such complications is crucial for comprehensive diabetes management and patient care.