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Delayed administration of basic fibroblast growth factor protects against N-methyl-D-aspartate neurotoxicity in
K Nozaki1, S P Finklestein, M F Beal
1Stroke Research, Massachusetts General Hospital, Boston 02114.
European Journal of Pharmacology
|March 2, 1993
Abstract:
Neuroprotective effects of basic fibroblast growth factor (bFGF) (200 mu/kg i.p.) were examined at different time points following intrastriatal injection of N-methyl-D-aspartate (NMDA) in seven-day-old rats. When administered 0.5 h before intrastriatal NMDA injection, 200 micrograms/kg of bFGF significantly reduced NMDA-induced lesion by 47% as compared with vehicle treatment. Posttreatment with the same dose of bFGF at 0, 0.5 or 1 h after NMDA injection also significantly reduced those lesions by 45, 35 or 26%, respectively, while no neuroprotective effects was observed when administered at 2 or 4 h after NMDA injection.