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Updated: Aug 9, 2026

Gastrointestinal Motility Monitor (GIMM)
Published on: December 2, 2010
Interleukin-1 alpha and tumour necrosis factor inhibit rat gastric fundus motility in vitro
P Montuschi1, P Preziosi, P Navarra
1Department of Pharmacology, Catholic University Medical School, Rome, Italy.
Abstract:
In this study, the effects of tumour necrosis factor (TNF) and interleukins 1 alpha and 6 (IL-1 alpha and IL-6) on rat gastric fundus motility were investigated in vitro. IL-1 alpha and TNF induced rapid dose-dependent inhibition of stomach motility, with maximal relaxation equal to that induced by 100 microM papaverin, and respective EC50s of 20 and 450 pg/ml. IL-6 had no effect on gastric motility up to a 3 ng/ml concentration.
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