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Ferrocins, new iron-containing peptide antibiotics produced by bacteria. Isolation, characterization and structure
S Tsubotani1, N Katayama, Y Funabashi
1Discovery Research Laboratories II, Takeda Chemical Industries, Ltd., Osaka, Japan.
The Journal of Antibiotics
|February 1, 1993
Abstract:
Novel iron-containing peptide antibiotics, ferrocins A, B, C and D, have been isolated from the culture filtrate of Pseudomonas fluorescens YK-310. These antibiotics were purified by butanol extraction, followed by column chromatography using adsorption resin, silica gel and preparative reverse-phase HPLC. The structures of ferrocins were elucidated using spectroscopic and degradative methods. Ferrocins contain three hydroxamate moieties per ferric ion which forms an octahedral iron complex.