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In vitro release of testosterone from suppository bases and in vivo absorption studies in human males
A Babar1, H M Fares, F M Plakogiannis
1Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201.
Journal of Pharmaceutical Sciences
|April 1, 1993
Abstract:
Diffusion rates of testosterone from various suppository bases with and without surfactants were determined. In a limited study, selected suppository formulations were evaluated for efficiency of rectal absorption of testosterone in three male volunteers ranging in age from 25 to 30 years. Significant reductions in the ratios of urinary metabolites to free testosterone were observed with polyethylene glycol 1000, esterified (C10-C18) fatty acids, and theobroma oil-based samples.