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Guillain-Barré syndrome (GBS) with bilateral optic neuritis and central white matter disease
1Department of Neurology, Wayne State University School of Medicine, Detroit, MI.
Abstract:
A patient with acute Guillain-Barré syndrome (GBS), recovering following plasmapheresis, developed bilateral optic neuritis with extensive CNS white matter lesions on MRI. This illness was associated with Mycoplasma pneumoniae infection. The rare association of GBS with CNS disease raises a possibility of a shared pathogenic CNS and PNS epitope in these cases.
Insights
Guillain-Barré syndrome (GBS) patients may develop optic neuritis and central nervous system (CNS) white matter lesions, potentially due to Mycoplasma pneumoniae infection. This suggests a shared pathogenic epitope between the central and peripheral nervous systems in rare GBS cases.
Area of Science:
- Neuroimmunology
- Infectious Neurology
Background:
- Guillain-Barré syndrome (GBS) is an autoimmune disorder affecting the peripheral nervous system (PNS).
- Central nervous system (CNS) involvement in GBS is rare, but infections like Mycoplasma pneumoniae can trigger neurological autoimmunity.