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A novel silent variant at codon 711 and a variant at codon 708 of the APP sequence detected in Spanish Alzheimer and
R Adroer1, C Lopez-Acedo, R Oliva
1Molecular Genetics Research Group, Faculty of Medicine, University of Barcelona, Spain.
Neuroscience Letters
|February 5, 1993
Abstract:
Pathogenic mutations have been identified in exons 16 and 17 of the beta-amyloid precursor protein (APP) gene in some cases of early onset Alzheimer's disease. Screening of these exons in a number of familial and sporadic cases of Alzheimer's disease in Spain, resulted in the identification of a novel silent variant at codon 711 whose relevance to the AD pathogenesis remains unclear. The 708 variant was also detected in one of normal controls.