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Acanthosis nigricans and hyperandrogenism in a pregnancy complicated by diabetes
1Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel.
Background:
Acanthosis nigricans and hyperandrogenism have been associated with diabetes mellitus accompanied by insulin resistance. However, these manifestations have rarely been reported to occur as a result of the insulin resistance of pregnancy.
Case:
A 31-year-old woman with diabetes mellitus exhibited severe insulin resistance during pregnancy. At 32 weeks, daily administration of 500 U insulin was required to maintain glycemic control. Skin lesions typical of acanthosis nigricans appeared, and free testosterone levels were elevated (10.3 pg/mL). These manifestations resolved after delivery.
Conclusion:
This case may demonstrate a correlation between reversible gestational insulin resistance and acanthosis nigricans.