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Familial peripartum cardiomyopathy after molar pregnancy
L S Massad1, C K Reiss, D G Mutch
1Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, Missouri.
Background:
The potential complications of molar pregnancy are numerous and well defined, but associated peripartum cardiomyopathy has not been reported.
Case:
A 16-year-old primigravida with a family history of peripartum cardiomyopathy requiring cardiac transplantation underwent suction curettage of a complete mole at 12 weeks' gestation. Three months after evacuation, she developed congestive heart failure. Radionuclide ventriculography demonstrated an ejection fraction of 30%, echocardiography revealed enlargement and ventricular hypokinesis, and a myocardial biopsy specimen contained hypertrophy and fibrosis without necrosis or active inflammation. The patient improved with medical therapy.
Conclusion:
Peripartum cardiomyopathy is a potential complication of molar pregnancy. In spite of the poor prognosis sometimes reported for this disease, good functional outcome may follow.
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