Related Experiment Video
Updated: Aug 13, 2026
Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
Published on: May 7, 2015
Hyperdynamic circulatory state after liver transplantation
1Mayo Clinic and Foundation, Rochester, Minnesota 55905.
Insights
Hepatic coagulopathy (HCS) is prevalent before liver transplantation (LT) and can emerge post-LT. HCS often resolves spontaneously after LT, suggesting conservative management is advisable.
Area of Science:
- Hepatology
- Transplantation Medicine
- Hematology
Background:
- Hepatic coagulopathy (HCS) is a frequent complication in patients undergoing liver transplantation (LT).
- HCS affects a significant majority of patients pre-LT and can also develop post-LT in those without pre-existing HCS.
Purpose of the Study:
- To investigate the incidence and natural course of hepatic coagulopathy (HCS) in the context of liver transplantation (LT).
- To evaluate the trend of HCS normalization after LT and provide recommendations for management.
Main Methods:
- Retrospective analysis of patient data undergoing liver transplantation.
- Monitoring of hepatic coagulopathy (HCS) markers pre- and post-LT.
Main Results:
- Hepatic coagulopathy (HCS) was present in 69% of patients pre-LT.
- HCS frequently developed in patients without pre-existing HCS during LT.
- A trend towards normalization of HCS was observed after LT.
Conclusions:
- Hepatic coagulopathy (HCS) is common in liver transplant recipients.
- Spontaneous reversal of HCS is a common trend post-LT.
- Avoidance of cardiodepressant treatment for HCS and awaiting spontaneous resolution is recommended, despite increased transfusion needs.
Abstract:
HCS is common pre-LT (69% of our patients) and frequently develops in NHCS patients during LT. There is a trend toward normalization of HCS after LT. Despite the increased requirement for postoperative blood transfusion in those patients with HCS, it may be prudent to avoid treatment of HCS with cardiodepressants and await its spontaneous reversal.
