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Updated: Aug 17, 2026

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
Published on: May 17, 2014
Translational regulation by mRNA/protein interactions in eukaryotic cells: ferritin and beyond
1European Molecular Biology Laboratory, Heidelberg, Germany.
Abstract:
The expression of certain eukaryotic genes is--at least in part--controlled at the level of mRNA translation. The step of translational initiation represents the primary target for regulation. The regulation of the intracellular iron storage protein ferritin in response to iron levels provides a good example of translational control by a reversible RNA/protein interaction in the 5' untranslated region of an mRNA. We consider mechanisms by which mRNA/protein interactions may impede translation initiation and discuss recent data suggesting that the ferritin example may represent the 'tip of the iceberg' of a more general theme for translational control.
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