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Endogenous digoxin-like immunoreactivity during pregnancy and at birth
J M Lupoglazoff1, E Jacqz-Aigrain, B Guyot
1Department of Clinical Pharmacology, Hôpital Robert Debré, Paris, France.
British Journal of Clinical Pharmacology
|March 1, 1993
Summary
Endogenous digoxin-like immunoreactivity (EDLI) is present in fetuses and newborns, with significantly higher concentrations in cord blood at birth. This suggests acute synthesis during delivery, potentially overestimating placental transfer calculations.
Area of Science:
- Obstetrics and Gynecology
- Neonatal Medicine
- Cardiovascular Physiology
Background:
- Endogenous digoxin-like immunoreactivity (EDLI) plays a role in cardiovascular regulation.
- Understanding EDLI levels in maternal-fetal pairs is crucial for assessing fetal well-being and drug transfer during pregnancy.
Purpose of the Study:
- To measure and compare EDLI levels in mothers and infants during pregnancy and at birth.
- To investigate the correlation between EDLI concentrations, gestational age, and maternal-fetal transfer.
Main Methods:
- Measurement of EDLI in maternal and fetal blood samples during pregnancy (n=38).
- Measurement of EDLI in maternal and cord blood samples at birth (n=45).
- Statistical analysis to determine correlations and significant differences in EDLI concentrations.
Main Results:
- EDLI was detected in 34% of mothers and 71% of fetuses during pregnancy, with no correlation to gestational age.
- At birth, EDLI was present in 22% of mothers and 98% of cord samples.
- Cord EDLI concentrations were significantly higher than maternal or fetal concentrations (P < 0.001).
Conclusions:
- Elevated EDLI in cord blood at birth suggests acute synthesis during labor and delivery.
- Current methods calculating placental digoxin transfer at birth may overestimate levels due to acute fetal synthesis.