Related Experiment Videos
The reproducibility of quinine bioavailability
G Paintaud1, G Alván, O Ericsson
1Department of Clinical Pharmacology, Karolinska Institute, Sweden.
British Journal of Clinical Pharmacology
|March 1, 1993
Summary
Quinine absorption is fast, complete, and reproducible in healthy volunteers following oral or intravenous administration. This study confirms extensive bioavailability and rapid plasma concentration for the antimalarial drug quinine.
Area of Science:
- Pharmacokinetics
- Drug Metabolism and Transport
- Clinical Pharmacology
Background:
- Quinine is a key antimalarial drug with established efficacy.
- Understanding quinine's absorption profile is crucial for optimizing dosing regimens.
- Variability in drug absorption can impact therapeutic outcomes.
Purpose of the Study:
- To quantify quinine absorption characteristics after oral and intravenous administration.
- To assess the rate, extent, and reproducibility of quinine absorption.
- To evaluate plasma drug concentrations and bioavailability in healthy volunteers.
Main Methods:
- Plasma quinine concentrations were measured in six healthy volunteers.
- Oral administration of 15 mg/kg quinine hydrochloride.
- Intravenous infusion of 15 mg/kg quinine dihydrochloride over 6 hours.
- Absorption rate determined by deconvolution analysis.
Main Results:
- Quinine absorption was complete in under 2 hours.
- Mean fraction available (F) was 0.76 (0.11) for oral doses.
- Maximum plasma concentrations (Cmax) were reached rapidly.
- High reproducibility of absorption with within-subject coefficient of variation <10% for Cmax, AUC, and F.
Conclusions:
- Quinine exhibits extensive, rapid, and reproducible absorption in healthy individuals.
- Oral administration of quinine leads to predictable pharmacokinetic profiles.
- These findings support the reliable use of quinine in clinical settings.