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A multiple dose comparison of ibuprofen and dihydrocodeine after third molar surgery
H J McQuay1, D Carroll, P G Guest
1Oxford Regional Pain Relief Unit, Churchill Hospital.
The British Journal of Oral & Maxillofacial Surgery
|April 1, 1993
Summary
Ibuprofen provided superior pain relief and fewer side effects compared to dihydrocodeine for post-oral surgery pain. This study highlights ibuprofen as a better choice for managing discomfort after third molar removal.
Area of Science:
- Pharmacology
- Oral Surgery
- Pain Management
Background:
- Post-surgical pain is common after third molar removal.
- Effective pain management is crucial for patient recovery and well-being.
Purpose of the Study:
- To compare the efficacy and safety of ibuprofen versus dihydrocodeine for pain management after third molar extraction.
- To determine the optimal analgesic for post-operative oral surgery pain.
Main Methods:
- A randomized, double-blind, crossover study involving 68 patients.
- Patients received ibuprofen 400 mg or dihydrocodeine 30 mg/60 mg, up to four times daily for 6 days.
- Pain and adverse effects were recorded post-operatively.
Main Results:
- Ibuprofen demonstrated significantly greater analgesia than dihydrocodeine on the day of surgery.
- Ibuprofen showed superior pain relief compared to dihydrocodeine 60 mg on days 4 and 5.
- Dihydrocodeine treatment resulted in significantly more adverse effects (nausea, vomiting, drowsiness) and higher discontinuation rates.
Conclusions:
- Ibuprofen is a more effective and safer option for managing pain after third molar removal compared to dihydrocodeine.
- Reduced adverse effects and superior analgesia support ibuprofen as a preferred analgesic for oral surgery patients.