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Production and regulation of gelatinase B by human T-cells

A M Montgomery1, H Sabzevari, R A Reisfeld

  • 1Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.

Here we describe for the first time the production of gelatinase B (MMP 9; 92-kDa type IV collagenase) by human peripheral blood T-lymphocytes. Expression of this enzyme was found to be dependent on the activation status of these T-cells and to be regulated by Interleukin-2.

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