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Niacin. I: Dissolution profiles of sustained-release niacin products by automated and manual procedures
1U.S. Food and Drug Administration, Division of Drug Analysis, St. Louis, MO 63101-2045.
Journal of AOAC International
|March 1, 1993
Abstract:
Automated and manual procedures were developed to obtain dissolution profiles of sustained-release niacin formulations. The procedures are based on the United States Pharmacopeia XXII apparatus 1 (basket) at 100 rpm with 900 mL 0.1N HCl as the dissolution medium. Filtered aliquots are read at 260 nm. No interference was found from excipients. The procedures are straightforward and will discriminate between sustained-release and regular niacin formulations.