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Studies on neurolathyrism

K Jahan1, K Ahmad

  • 1Institute of Nutrition and Food Science, University of Dhaka, Bangladesh.

Environmental Research
|February 1, 1993
PubMed
Summary
This summary is machine-generated.

Neurolathyrism, a paralysis linked to Lathyrus sativus seeds, was replicated in animals by inducing ascorbic acid deficiency. This breakthrough enables studying the neurological condition and its toxin, beta-N-Oxalyl-L-alpha,beta-diaminopropionic acid.

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Area of Science:

  • Neuroscience
  • Toxicology
  • Nutritional Science

Background:

  • Neurolathyrism is a neurological disorder caused by prolonged consumption of Lathyrus sativus seeds.
  • The condition leads to severe muscle rigidity and lower limb paralysis.
  • The primary toxin identified is beta-N-Oxalyl-L-alpha,beta-diaminopropionic acid, but an animal model was previously lacking.

Purpose of the Study:

  • To establish a reproducible experimental animal model for neurolathyrism.
  • To investigate the role of ascorbic acid in the development of neurolathyrism.
  • To understand the mechanism of action of Lathyrus sativus seeds toxicity.

Main Methods:

  • Guinea pigs and primates requiring external ascorbic acid were made subclinically deficient.
  • Experimental animals were fed Lathyrus sativus seeds or their extracts.

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  • The effects of autoclaving Lathyrus sativus seeds with lime on toxin removal were assessed.

    • Main Results:

    • Experimental neurolathyrism was successfully induced in ascorbic acid-deficient guinea pigs and primates.
    • Feeding Lathyrus sativus seeds or extracts to these animals resulted in neurological symptoms.
    • Autoclaving Lathyrus sativus seeds with lime effectively neutralized the toxin.

    Conclusions:

    • Subclinical ascorbic acid deficiency is crucial for the development of neurolathyrism in susceptible species.
    • This study provides the first experimental animal model for neurolathyrism.
    • The findings offer new avenues for understanding and potentially preventing neurolathyrism.