Topical acetone for control of life-threatening vaginal hemorrhage from recurrent gynecologic cancer

Two patients with intractable, life-threatening vaginal bleeding from recurrent gynecologic cancer were successfully treated with application of topical acetone or placement of an acetone-soaked pack, with immediate control of hemorrhage and no immediate side effects other than pain. No long-term adverse effects were noted. Acetone application may control vaginal bleeding from recurrent pelvic malignancy, particularly in previously radiated patients who cannot safely be treated with additional radiotherapy or when embolic techniques are not immediately available or practical.