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Autonomic dysfunction in gastrointestinal motility disorders

A E Bharucha1, M Camilleri, P A Low

  • 1Department of Neurology, Mayo Clinic, Rochester, MN 55905.

Gut
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

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Autonomic dysfunction is prevalent in gastrointestinal motility disorders, particularly in diabetic patients. However, autonomic function testing offers limited diagnostic value for irritable bowel syndrome and most motility disorders.

Area of Science:

  • Gastroenterology
  • Neurology
  • Clinical Medicine

Background:

  • Gastrointestinal motility disorders are common, often associated with autonomic dysfunction.
  • The diagnostic utility of autonomic function testing in these patients requires clarification.

Purpose of the Study:

  • To determine the prevalence of autonomic dysfunction in patients with suspected gastrointestinal motility disorders.
  • To assess the diagnostic value of autonomic function testing in this population.

Main Methods:

  • Retrospective review of 113 patients with suspected gastrointestinal motility disorders.
  • Gastrointestinal manometry (fasting and fed) and autonomic function tests (sympathetic, cardiovagal) were performed.
  • Data analyzed using standard scoring and logistic discriminant analysis.

Related Experiment Videos

Main Results:

  • A significant but modest correlation was found between autonomic and motility scores (r=0.28), stronger in diabetics (r=0.67).
  • Autonomic dysfunction was observed in various subgroups, including irritable bowel syndrome, diabetes, and neurological syndromes.
  • Autonomic testing did not significantly improve diagnostic accuracy for irritable bowel syndrome but showed slight potential for neuropathic dysmotilities.

Conclusions:

  • Autonomic dysfunction is present in a notable proportion of patients with gastrointestinal motility disorders.
  • Autonomic function testing has limited added diagnostic value beyond standard clinical and manometric evaluations for most motility disorders.
  • Further research is warranted on the etiological role of autonomic dysfunction in specific motility disorders like IBS.