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Altered platelet function associated with the bronchial hyperresponsiveness accompanying nocturnal asthma
P Gresele1, M Dottorini, M L Selli
1International Inter-University Centre on Thrombosis and Haemostasis, Italy.
The Journal of Allergy and Clinical Immunology
|April 1, 1993
Summary
Platelet activation occurs during nocturnal asthma awakenings, linked to increased bronchial reactivity. This platelet dysfunction, not seen in healthy individuals, suggests a role in asthma symptoms.
Area of Science:
- Pulmonary Medicine
- Hematology
Background:
- Nocturnal awakening is a common asthma symptom with unclear mechanisms.
- Platelet activation markers are investigated as a potential link.
Purpose of the Study:
- To investigate the association between nocturnal asthma awakenings and platelet function.
- To explore platelet activation markers during nocturnal asthma.
Main Methods:
- Studied 10 nocturnal asthma patients and 10 controls at 10 PM, 4 AM, and 10 AM.
- Measured lung function (FEV1), bronchial reactivity, platelet aggregation, and platelet activation markers (beta-thromboglobulin, platelet factor 4).
Main Results:
- Altered platelet function and activation occurred at 4 AM in asthma patients, coinciding with peak bronchial reactivity.
- Asthmatic subjects showed reduced platelet aggregation response to collagen and activating factor.
- Lower intraplatelet beta-thromboglobulin levels at 4 AM correlated with reduced peak expiratory flow and increased bronchial reactivity.
Conclusions:
- Platelet activation is associated with nocturnal asthma.
- Platelets may play a significant role in the pathophysiology of nocturnal asthma.
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