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Immunogenetics of familial rheumatoid arthritis: a study of 41 multicase families
V Taneja1, N K Mehra, R R Singh
1Histocompatibility and Immunogenetics Unit, All India Institute of Medical Sciences, New Delhi.
The Journal of Rheumatology
|February 1, 1993
Abstract:
HLA haplotypes were studied in 41 unrelated families from North India with multiple cases of rheumatoid arthritis. Affected sibpairs shared parental HLA haplotypes more often than expected (chi 2 = 13.6) according to Mendelian segregation. Using the method of sibpair ratio, nonrandom segregation of parental haplotypes was observed among affected sibs. HLA-DR4 was observed in 70% of the probands while among DR4 negative probands, DR10 occurred more frequently. However no specific haplotypic association with the disease was observed in these families.