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Related Experiment Videos

Apomorphine test for dopaminergic responsiveness: a dose assessment study

U Bonuccelli1, P Piccini, P Del Dotto

  • 1Institute of Clinical Neurology, University of Pisa, Italy.

Movement Disorders : Official Journal of the Movement Disorder Society
|April 1, 1993
PubMed
Summary

The subcutaneous apomorphine test, particularly at 50 micrograms/kg, effectively predicts levodopa response in parkinsonian syndromes. This diagnostic tool demonstrated an 86.4% accuracy in identifying idiopathic Parkinson's disease.

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Idiopathic Parkinson's disease (IPD) diagnosis is challenging, often relying on levodopa response.
  • Predicting levodopa responsiveness is crucial for accurate parkinsonian syndrome diagnosis.

Purpose of the Study:

  • To evaluate subcutaneous apomorphine's utility in predicting levodopa responsiveness in parkinsonian syndromes.
  • To assess apomorphine's diagnostic accuracy for IPD.

Main Methods:

  • 37 parkinsonism patients received subcutaneous apomorphine (10, 50, 100 µg/kg) or placebo.
  • Motor response was evaluated for 90 minutes post-administration.
  • Apomorphine response was compared with 12-month levodopa therapy outcomes and final diagnoses.

Main Results:

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  • 27 out of 37 patients responded positively to apomorphine, primarily at 50 or 100 µg/kg.
  • The 50 µg/kg dose showed promise due to fewer side effects than 100 µg/kg.
  • A positive apomorphine test correlated strongly with positive levodopa response and confirmed IPD diagnosis (86.4% predictive accuracy).

Conclusions:

  • Subcutaneous apomorphine at 50 µg/kg is a valuable tool for differential diagnosis in parkinsonian syndromes.
  • The apomorphine test aids in predicting levodopa responsiveness, improving diagnostic accuracy for IPD.