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Prescribing considerations in fluoroquinolone therapy

L O Gentry1

  • 1Department of Medicine, Baylor College of Medicine, Houston, Texas.

Pharmacotherapy
|March 1, 1993
PubMed
Summary

New oral fluoroquinolones offer effective treatment for various infections, matching parenteral drugs. This approach allows for earlier intensive care unit discharge, reducing costs and improving patient quality of life.

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Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Clinical Medicine

Background:

  • Parenteral cephalosporins and broad-spectrum agents are standard for treating common infections.
  • The efficacy and safety of newer oral fluoroquinolones in comparison are under investigation.
  • Sequential parenteral to oral therapy is a developing strategy for hospitalized patients.

Purpose of the Study:

  • To compare the efficacy of new oral fluoroquinolones against parenteral cephalosporins and other broad-spectrum agents.
  • To evaluate the utility of sequential parenteral to oral therapy in diverse patient populations.
  • To assess the impact of oral fluoroquinolone therapy on healthcare resource utilization and patient outcomes.

Main Methods:

  • Comparative clinical trials were conducted.
  • Efficacy was assessed for urinary tract, lower respiratory tract, and skin infections.
  • Treatment of prostatitis and osteomyelitis was also evaluated.

Main Results:

  • New oral fluoroquinolones demonstrated comparable efficacy to parenteral cephalosporins and other broad-spectrum agents.
  • Effective treatment was observed for gram-negative and selected gram-positive pathogens.
  • Sequential parenteral to oral therapy proved beneficial, even in critically ill intensive care unit patients.

Conclusions:

  • Oral fluoroquinolones are a viable alternative to parenteral antibiotics for several common infections.
  • Sequential therapy facilitates earlier transfer from intensive care, shortening hospital stays and reducing costs.
  • High bioavailability of agents like ofloxacin allows for identical oral and parenteral dosing.

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