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Increase in antioxidant activity in procainamide-treated rats

K Magner-Wróbel¹, M Toborek, M Drózdz

¹Department of Biochemistry and Chemistry, Silesian Medical Academy, Poland.

Pharmacology & Toxicology

|February 1, 1993

Summary

Procainamide treatment in rats increased oxidative stress markers, including lipid peroxides and antioxidant enzyme activity. These findings suggest that heightened free radical activity may contribute to procainamide-induced side effects.

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Area of Science:

Biochemistry
Pharmacology
Toxicology

Background:

Drug metabolism can generate reactive oxygen species, potentially leading to adverse effects.
Procainamide-induced autoimmunity is suspected to be linked to its in vivo oxidation.

Purpose of the Study:

To investigate the biochemical basis of procainamide-induced side effects.
To evaluate oxidative stress markers in rats treated with procainamide.

Main Methods:

Assessed thiobarbituric acid reacting substances (TBARS) in plasma and liver.
Measured erythrocyte and liver superoxide dismutase, catalase, and selenium-dependent glutathione peroxidase (Se-GPX) activities.
Evaluated plasma antioxidant activity in procainamide-treated rats.

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Main Results:

Procainamide administration elevated liver lipid peroxide levels.
Increased activity was observed in liver catalase and erythrocyte superoxide dismutase.
Plasma antioxidant activity was also enhanced, while erythrocyte catalase activity decreased.

Conclusions:

Procainamide treatment induces oxidative stress in rats.
Increased free radical activity may play a role in the development of procainamide-induced side effects.
Further research is warranted to elucidate the precise mechanisms involved.