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Hypolipidemic activity of 1-acyl- and 1,2-diacyl-3,5-pyrazolidinediones
R A Izydore1, J A Bernal-Ramirez, W A Okwisa
1Department of Chemistry, North Carolina Central University, Durham.
Die Pharmazie
|February 1, 1993
Abstract:
A series of substituted 1-acyl- and 1,2-diacyl-3,5-pyrazolidinediones were found to have hypolipidemic properties lowering both serum cholesterol and triglyceride levels in rodents. For optimal activity of the pyrazolidinediones, both nitrogen atoms of the ring needed to be substituted preferentially with MeCO groups. This compound lowered rat VLDL but did not elevate HDL cholesterol content.