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Oral contraceptives and the dexamethasone suppression test

M Ansseau1, D Leboulle, J Sulon

  • 1Psychiatric Unit, Centre Hospitalier Universitaire du Sart Tilman, Liège, Belgium.

Psychoneuroendocrinology
|January 1, 1993
PubMed
Summary

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Oral contraceptives significantly increase basal total cortisol levels but do not appear to affect dexamethasone suppression test (DST) results in healthy women. This study investigated the impact of oral contraceptives on DST outcomes.

Area of Science:

  • Endocrinology
  • Reproductive Health

Background:

  • Oral contraceptives are widely used by women of reproductive age.
  • Estrogen-containing oral contraceptives may influence hormonal assays.
  • The effect of oral contraceptives on the dexamethasone suppression test (DST) remains understudied.

Purpose of the Study:

  • To investigate the influence of estrogen-containing oral contraceptives on the results of the 1 mg dexamethasone suppression test (DST).

Main Methods:

  • 1 mg DSTs were administered to two groups of healthy women: 14 taking oral contraceptives and 14 age-matched controls not taking oral contraceptives.
  • Basal and post-DST cortisol levels (total and free) were measured.

Main Results:

  • Women taking oral contraceptives exhibited significantly higher mean 0800h basal total cortisol levels compared to controls.
Keywords:
Adrenal Cortex Hormones--analysisBelgiumBiologyContraceptionContraceptive MethodsDeveloped CountriesDexamethasone AcetateEndocrine SystemEuropeExaminations And DiagnosesFamily PlanningHormonesLaboratory Examinations And DiagnosesLaboratory ProceduresOral ContraceptivesPhysiologyWestern Europe

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  • Mean free cortisol levels did not significantly differ between the groups.
  • No significant differences in DST results were observed between the oral contraceptive users and the control group at 1600h.

    • Conclusions:

    • Oral contraceptives exert a strong influence on basal total cortisol levels.
    • The use of oral contraceptives does not appear to significantly impact the results of the 1 mg DST in healthy women.