Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Unexpectedly prolonged thrombin time]

A Barth1, M Furlan, B Lämmle

  • 1Hämatologisches Zentrallabor der Universität, Inselspital, Bern.

Schweizerische Medizinische Wochenschrift
|March 27, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improved Limit on the Effective Electron Neutrino Mass with the ECHo-1k Experiment.

Physical review letters·2026
Same author

First report of ceftazidime-avibactam resistance in non-mutated bla<sub>KPC-3</sub> K. pneumoniae recovered from patients with no prior treatment, in Latin America.

Diagnostic microbiology and infectious disease·2025
Same author

Ceftazidime-avibactam tolerance and persistence among difficult-to-treat KPC-producing Klebsiella pneumoniae clinical isolates from bloodstream infections.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2024
Same author

Micro and nano-scale compartments guide the structural transition of silk protein monomers into silk fibers.

Nature communications·2022
Same author

ADAMTS13 activity, von Willebrand factor, factor VIII and D-dimers in COVID-19 inpatients.

Thrombosis research·2020
Same author

N-Methyl-D-Aspartate Receptor Encephalitis with Psychiatric Symptoms and an Ovarian Teratoma Detected by MRI in a 17-Year-Old Girl.

Neuropediatrics·2019
Same journal

Respiratory function test in the case of temporary phrenic nerve contusion, associated with pneumoperitoneum; About the diagnostic value of laparoscopy.

Schweizerische medizinische Wochenschrift·2010
Same journal

Treatment of pulmonary tuberculosis and pleurisy by means of temporary paralysis of the diaphragm, supported by the pneumoperitoneum.

Schweizerische medizinische Wochenschrift·2010
Same journal

Boeck's disease as a tuberculous syndrome.

Schweizerische medizinische Wochenschrift·2010
Same journal

Enteral primary tubercular complexes

Schweizerische medizinische Wochenschrift·2010
Same journal

Tuberculous stenoses of the large bronchi.

Schweizerische medizinische Wochenschrift·2010
Same journal

About the enzyme action.

Schweizerische medizinische Wochenschrift·2010
See all related articles

The thrombin time assay detects issues in blood clotting. Prolonged results can indicate heparin, fibrinogen problems, or fibrin degradation, aiding in differential diagnosis.

Area of Science:

  • Hematology
  • Clinical Chemistry
  • Coagulation Science

Background:

  • The thrombin time (TT) assay is a crucial diagnostic tool for evaluating the terminal phase of plasmatic coagulation.
  • Understanding the differential diagnosis of prolonged TT is essential for accurate patient management.

Observation:

  • Prolongation of the thrombin time assay can stem from several distinct causes.
  • These causes include inhibition of thrombin activity, fibrinogen abnormalities, and impaired fibrin polymerization.

Findings:

  • Inhibitors of thrombin, such as heparin or heparin-like anticoagulants, can prolong TT.
  • Qualitative (dysfibrinogenemia) and quantitative (hypo-/afibrinogenemia) fibrinogen disorders are significant causes.
  • Delayed fibrin polymerization, resulting from degradation products, paraproteins, or antibodies, also extends TT.

Related Experiment Videos

Implications:

  • Accurate interpretation of prolonged TT aids in diagnosing bleeding disorders and identifying anticoagulant effects.
  • Distinguishing between these causes is vital for appropriate therapeutic interventions.
  • Further investigation may be needed to confirm specific etiologies, guiding personalized treatment strategies.