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Updated: Jul 4, 2026
Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange
Published on: April 27, 2017
[The independent variability of different karyotypic characteristics during the spontaneous neoplastic evolution of
Abstract:
The dynamics of some karyotype characteristics throughout the spontaneous neoplastic evolution of embryonal fibroblasts of different mouse strains was studied using a differential staining of chromosomes. The independent variability of chromosome modal numbers, the number of polyploid cells in the cell line, the number of chromosomal rearrangements within one cell, the activity of formation of different types of chromosomal rearrangements and the activity of interactions of the homologous chromosomes in 15 studied cell lines were revealed. Possible levels of variability regulations of different karyotype characteristics are discussed.
