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Elevated serum sialic acid in idiopathic acute iridocyclitis
S Lam1, H H Tessler, M D Farber
1Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine.
Acta Ophthalmologica
|February 1, 1993
Summary
Serum sialic acid levels were elevated in patients with idiopathic acute iridocyclitis, suggesting this eye condition may affect multiple organs. This finding indicates potential systemic effects beyond the eye.
Area of Science:
- Ophthalmology
- Immunology
- Biochemistry
Background:
- Idiopathic acute iridocyclitis is an ocular inflammatory condition.
- The systemic involvement of idiopathic acute iridocyclitis is not well understood.
Purpose of the Study:
- To investigate serum sialic acid levels in patients with idiopathic acute iridocyclitis.
- To explore potential systemic effects of idiopathic acute iridocyclitis.
Main Methods:
- Serum sialic acid levels were measured.
- Patients with idiopathic acute iridocyclitis (n=12) were compared to normal controls (n=18).
Main Results:
- Serum sialic acid levels were significantly elevated in patients with idiopathic acute iridocyclitis compared to controls.
- Animal studies suggest intraocular inflammation alone does not elevate serum sialic acid.
Conclusions:
- Elevated serum sialic acid in idiopathic acute iridocyclitis suggests a systemic component.
- Idiopathic acute iridocyclitis may be a multiorgan disease with systemic effects.