Related Experiment Videos
Penetration of fusidic acid into human brain tissue and cerebrospinal fluid
T Mindermann1, W Zimmerli, Z Rajacic
1Neurochirurgische Universitätsklinik, Kantonsspital Basel, Switzerland.
Acta Neurochirurgica
|January 1, 1993
Abstract:
Penetration of fusidic acid into brain tissue in six patients and cerebrospinal fluid in seven patients was determined. Tissue samples, taken during surgery revealed drug levels at about 7% of simultaneous serum concentrations. In contrast, cerebrospinal fluid concentrations were below 1% of serum levels. Since serum- and tissue levels of fusidic acid were far above the minimal inhibitory concentration (MICs) of staphylococci and streptococci, and since it has a long serum half-life of about 10 hours, it is a promising candidate for prophylaxis in neurosurgery.