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Splenic lymphoid hyperplasias versus lymphomas/leukemias. A diagnostic guide
1Department of Anatomic Pathology, Alta Bates Medical Center, Berkeley, California 94705.
American Journal of Clinical Pathology
|April 1, 1993
Summary
Accurate spleen lymphoid infiltrate diagnosis requires high-quality tissue, understanding distribution patterns in white and red pulp, and considering cell types. Immunophenotypic and molecular studies are crucial for confirming histologic findings.
Area of Science:
- Pathology
- Hematology
Background:
- Splenomegaly diagnosis relies on identifying lymphoid infiltrates.
- Understanding the distribution of these infiltrates is key.
Purpose of the Study:
- To outline essential factors for accurate diagnosis of splenic lymphoid infiltrates.
- To emphasize the importance of histologic patterns, cell types, and advanced studies.
Main Methods:
- Ensuring high-quality spleen fixation and tissue sections.
- Analyzing the distribution of lymphoid infiltrates within the spleen (white pulp vs. red pulp).
- Utilizing differential diagnostic schemes based on histology and cell morphology.
Main Results:
- Accurate diagnosis depends on technical quality and pathologist's awareness of distribution.
- Histologic pattern and cell type are critical for differential diagnosis.
- Immunophenotypic and molecular studies verify and refine diagnoses.
Conclusions:
- A multi-faceted approach combining technical quality, morphologic analysis, and advanced techniques ensures accurate splenic lymphoid infiltrate diagnosis.
- Histologic evaluation, supported by immunophenotyping and molecular genetics, is imperative for definitive diagnosis.