Prognosis in well differentiated noninvasive carcinoma of the bladder based on chromosomal analysis

In this series of 27 consecutive patients with well differentiated noninvasive carcinoma of the bladder, cytogenetic analysis repeatedly performed showed marker chromosomes in curative cytoscopic resections of 15 of the patients. In 14 of the 15 patients, recurrent carcinoma developed. Of the 12 patients without markers, one patient had a recurrence; the remaining 11 have been free of recurrence up to eight years after diagnosis. In this long term, although limited, experience with early carcinoma of the bladder, marker chromosomes have been a highly accurate prognostic aid.