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Intestinal permeability in allergic rats: nerve involvement in antigen-induced changes
S E Crowe1, K Soda, A M Stanisz
1Intestinal Disease Research Unit, McMaster University, Hamilton, Ontario, Canada.
The American Journal of Physiology
|April 1, 1993
Summary
Egg albumin-sensitized rats showed increased intestinal permeability and 51Cr-EDTA uptake during anaphylaxis. Neural factors, modulated by tetrodotoxin, influenced antigen uptake, suggesting a role in intestinal allergic reactions.
Area of Science:
- Gastroenterology
- Immunology
- Neuroscience
Background:
- Intestinal anaphylaxis involves complex immune responses.
- Increased intestinal permeability is a hallmark of allergic reactions.
Purpose of the Study:
- To investigate the role of neural factors in intestinal permeability during anaphylaxis.
- To compare 51Cr-EDTA uptake in egg albumin-sensitized rats versus controls.
Main Methods:
- In vivo jejunal uptake of 51Cr-labeled EDTA was measured.
- Intraluminal antigen challenge was performed.
- Tetrodotoxin was used to assess neural involvement.
Main Results:
- Sensitized rats exhibited higher baseline 51Cr-EDTA uptake, indicating increased intestinal permeability.
- Antigen challenge caused a 15-fold increase in 51Cr-EDTA uptake in sensitized rats.
- Tetrodotoxin inhibited antigen-induced molecule uptake, suggesting neural mediation.
Conclusions:
- Neural factors play a significant role in modulating intestinal permeability during anaphylaxis.
- The findings suggest a neuro-immune interaction in the gut during allergic responses.