Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
Insertion of Single-pass Transmembrane Proteins in the RER01:26

Insertion of Single-pass Transmembrane Proteins in the RER

Integral membrane proteins are proteins adhered to the lipid bilayer of a cell organelle or membrane. They can be of two types: transmembrane integral proteins that span the lipid bilayer and monotopic proteins that are attached to either side of the membrane but do not pass through it.
Integral transmembrane proteins possess transmembrane and extra membrane domains. The transmembrane domains are primarily made of 20-25 hydrophobic amino acids arranged in a helical secondary confirmation. These...
Post-translational Translocation of Proteins to the RER01:27

Post-translational Translocation of Proteins to the RER

A sizable fraction of proteins destined for ER are first synthesized in the cell cytosol and then transported across the ER membrane–a process called post-translational translocation. Similar to cotranslationally translocated proteins, these proteins also use the Sec translocon complex to enter the ER lumen.
Targeting proteins to the ER
Hsp40 and Hsp70 chaperone molecules bind the translated proteins in the cytosol to prevent their folding. The chaperone binding helps to keep the signal...
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying subtypes of Hypersomnolence Disorder: a clustering analysis.

Sleep medicine·2019
Same author

Effects of oral temazepam on slow waves during non-rapid eye movement sleep in healthy young adults: A high-density EEG investigation.

International journal of psychophysiology : official journal of the International Organization of Psychophysiology·2016
Same author

Effects of oral temazepam on sleep spindles during non-rapid eye movement sleep: A high-density EEG investigation.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2015
Same author

Mechanism of thrombocytopenia in chronic hepatitis C as evaluated by the immature platelet fraction.

International journal of laboratory hematology·2012
Same author

Iron deficiency and the measurement of iron status.

Nutrition research reviews·2008
Same author

Identification of uterine leiomyoma genes developmentally reprogrammed by neonatal exposure to diethylstilbestrol.

Reproductive sciences (Thousand Oaks, Calif.)·2008
Same journal

Dupilumab Emerges as an Effective Antibody Therapy for Eosinophilic Esophagitis.

Annual review of medicine·2026
Same journal

CAR T Cell Toxicities and Emerging Treatment Strategies.

Annual review of medicine·2026
Same journal

Transthyretin Amyloid Cardiomyopathy: A Rapidly Evolving Landscape.

Annual review of medicine·2026
Same journal

Accessibility of Somatic Genetic Testing for Cancer Treatment Decisions.

Annual review of medicine·2026
Same journal

Diffuse Parenchymal Lung Disease: Updates in Pathophysiology and Management.

Annual review of medicine·2026
Same journal

Revascularization for Ischemic Cardiomyopathy: Disproving the 45-Year-Old Concept of Hibernating Myocardium.

Annual review of medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 23, 2026

Fluorescence-Activated Cell Sorting-Radioligand Treated Tissue (FACS-RTT) to Determine the Cellular Origin of Radioactive Signal
12:04

Fluorescence-Activated Cell Sorting-Radioligand Treated Tissue (FACS-RTT) to Determine the Cellular Origin of Radioactive Signal

Published on: September 10, 2021

Serum transferrin receptor

J D Cook1, B S Skikne, R D Baynes

  • 1Department of Medicine, Kansas University Medical Center, Kansas City 66160-7402.

Annual Review of Medicine
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Measuring soluble transferrin receptor in serum quantifies iron deficiency and erythropoiesis. This blood test aids in diagnosing anemia and assessing red blood cell production, offering a less invasive alternative to bone marrow exams.

More Related Videos

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability
10:56

Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability

Published on: June 7, 2022

Related Experiment Videos

Last Updated: Jun 23, 2026

Fluorescence-Activated Cell Sorting-Radioligand Treated Tissue (FACS-RTT) to Determine the Cellular Origin of Radioactive Signal
12:04

Fluorescence-Activated Cell Sorting-Radioligand Treated Tissue (FACS-RTT) to Determine the Cellular Origin of Radioactive Signal

Published on: September 10, 2021

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability
10:56

Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability

Published on: June 7, 2022

Area of Science:

  • Biochemistry
  • Hematology
  • Clinical Diagnostics

Background:

  • The transferrin receptor regulates cellular iron uptake.
  • A soluble form of the transferrin receptor (sTfR) is detectable in human serum.
  • sTfR levels correlate with total body tissue receptor mass.

Purpose of the Study:

  • To evaluate serum transferrin receptor as a diagnostic marker for iron deficiency.
  • To assess the utility of sTfR in quantifying erythropoiesis.
  • To differentiate anemia of chronic disease from iron deficiency anemia.

Main Methods:

  • Detection of soluble transferrin receptor in human serum using sensitive immunoassays.
  • Correlation of serum receptor levels with iron status and erythropoietic activity.
  • Comparison of sTfR measurements with bone marrow examination.

Main Results:

  • Serum receptor levels increase significantly with tissue iron deficiency and expanded erythroid marrow.
  • sTfR provides a quantitative measure of functional iron deficiency.
  • sTfR distinguishes iron deficiency anemia from anemia of chronic disease.
  • In the absence of iron deficiency, sTfR quantifies total erythropoiesis sensitively.

Conclusions:

  • Serum transferrin receptor is a valuable, non-invasive biomarker for assessing iron status and erythropoiesis.
  • sTfR measurement aids in diagnosing and differentiating anemias.
  • Combined with ferritin, sTfR can help determine the prevalence of iron deficiency anemia in populations.