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X-ray fluorescence determination of bromine traces in pharmaceutical formulations containing sodium diclofenac
M A Raggi1, F Lucchini, P Da Re
1Department of Pharmaceutical Sciences, University of Bologna, Italy.
Bollettino Chimico Farmaceutico
|January 1, 1993
Abstract:
The X-ray fluorescence spectroscopy (XRF) on solid samples is applied to the organic bromine impurities assay on pharmaceutical formulations of sodium diclofenac (DCF). A wide range of Br contents (7-1564 ppm) in the tablets is obtained, depending on manufacturer source and batch preparation. As the impurities concern only the sodium diclofenac employed, and the presence of Br might be a toxicity index arising from the synthetic procedure, the assay of each DCF batch is suggested.