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Endothelin in human nasal mucosa

J Mullol1, B A Chowdhury, M V White

  • 1Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.

American Journal of Respiratory Cell and Molecular Biology
|April 1, 1993
PubMed
Summary

Endothelin (ET) in human nasal tissue stimulates mucous and serous cell secretion and may regulate blood vessel tone. This peptide is found in nasal arteries, glands, and blood vessels.

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Area of Science:

  • Molecular Biology
  • Physiology
  • Otorhinolaryngology

Background:

  • Endothelin (ET) is a peptide known for its potent vasoconstrictor and bronchoconstrictor effects.
  • Its specific roles in human nasal mucosal tissue were not fully understood.

Purpose of the Study:

  • To investigate the localization and function of Endothelin (ET) in human inferior turbinate nasal mucosa.
  • To determine ET's effect on nasal mucosal secretion and vascular regulation.

Main Methods:

  • Immunohistochemistry to localize immunoreactive ET.
  • Autoradiography with [125I]ET to identify ET receptors.
  • In situ hybridization to detect ET-1 mRNA.
  • Short-term cultures of human nasal turbinates to assess secretory responses.

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Main Results:

  • ET-1 was localized in nasal arteries, submucosal gland serous cells, and venous sinusoids.
  • ET receptors were found in submucosal glands, venous sinusoids, and arterioles.
  • ET-1 and ET-2 stimulated lactoferrin and mucous glycoprotein release from serous and mucous cells.

Conclusions:

  • Endothelin is present in human nasal mucosa's vascular endothelium and glandular serous cells.
  • ET acts on nasal glandular receptors to stimulate both serous and mucous secretion.
  • ET likely plays a role in regulating nasal vasomotor tone.