Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement and glomerulonephritis--an update

R H McLean1

  • 1Division of Pediatric Nephrology, Johns Hopkins University, School of Medicine, Baltimore.

Pediatric Nephrology (Berlin, Germany)
|April 1, 1993
PubMed
Summary

The complement (C) system, crucial for immunity, involves components with similar structures and functions. Understanding C deficiencies aids in diagnosing and treating related diseases, especially in children.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pericardial tamponade: an unusual complication of lobectomy for lung cancer.

The Annals of thoracic surgery·1999
Same author

Gastric cancer: an overview with emphasis on early gastric cancer.

Maryland medical journal (Baltimore, Md. : 1985)·1998
Same author

Hemolytically inactive C4B complement allotype caused by a proline to leucine mutation in the C5-binding site.

The Journal of biological chemistry·1994
Same author

Prevalence of a mutation causing C2 deficiency in systemic lupus erythematosus.

The Journal of rheumatology·1994
Same author

Clinical expression of systemic lupus erythematosus in patients with C4A deficiency.

Medicine·1993
Same author

Hypoproteinemia in the hemolytic-uremic syndrome of childhood.

Pediatric nephrology (Berlin, Germany)·1993

Area of Science:

  • Immunology
  • Genetics
  • Clinical Medicine

Background:

  • The complement (C) system is a vital part of innate immunity.
  • Its components and genetic makeup are complex and linked to various diseases.
  • Research highlights the need to understand C system's role in health and illness.

Purpose of the Study:

  • To review current knowledge on complement component nature, structure, and function.
  • To explore similarities between complement components and their genes.
  • To connect C abnormalities and deficiencies to clinical problems and pathogenic roles.

Main Methods:

  • Literature review of complement system research.
  • Analysis of structural and functional similarities of C components and genes.
  • Correlation of genetic defects with C deficiencies and clinical manifestations.

Main Results:

  • Complement components share structural and functional similarities, mirrored in their genes.
  • Acquired and genetic C abnormalities offer insights into patient conditions.
  • Identification of normal variants and gene defects advances understanding of C's role in disease.

Conclusions:

  • Understanding the complement system is essential for diagnosing and managing related diseases.
  • Genetic C abnormalities are often identified in childhood.
  • Knowledge of the C system aids pediatric nephrologists in patient care.

Related Experiment Videos