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Related Experiment Videos

TiN coating: surface characterization and haemocompatibility

I Dion1, F Rouais, L Trut

  • 1INSERM U.306, Université de Bordeaux II, France.

Biomaterials
|February 1, 1993
PubMed
Summary
This summary is machine-generated.

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Chemical vapor deposition titanium nitride coatings for rotary blood pumps show good hemocompatibility. Despite surface irregularities, this material is a promising candidate for left ventricular assist devices after further refinement.

Area of Science:

  • Biomaterials Science
  • Cardiovascular Engineering
  • Surface Chemistry

Background:

  • Left ventricular assist devices (LVADs) are crucial for end-stage heart failure treatment.
  • The Maillard-Wankel rotary pump design necessitates advanced construction materials.
  • Titanium nitride (TiN) and graphite were selected for their specific properties.

Purpose of the Study:

  • To characterize chemical vapor deposition (CVD) titanium nitride coatings.
  • To evaluate the in vitro hemocompatibility of CVD TiN.
  • To correlate physico-chemical and biological performance for potential LVAD applications.

Main Methods:

  • Morphological, roughness, and crystallographic analysis of CVD TiN.
  • Chemical composition assessment of the TiN coating.

Related Experiment Videos

  • In vitro hemocompatibility testing: protein adsorption, platelet retention, and hemolysis assays.

    • Main Results:

    • CVD TiN coating exhibited surface irregularities.
    • In vitro tests demonstrated good hemocompatibility, with blood being well-tolerated.
    • Protein adsorption, platelet retention, and hemolysis levels were within acceptable ranges.

    Conclusions:

    • CVD titanium nitride coatings are well-tolerated by blood.
    • Surface irregularities did not impede hemocompatibility significantly.
    • TiN is a viable candidate material for rotary blood pumps, requiring further optimization.