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Related Experiment Videos

Functional localization in the Onufrowicz nucleus in man

M Iwata1, K Inoue, T Mannen

  • 1Department of Neurology, University of Tokyo School of Medicine, Japan.

Clinical Neuropathology
|March 1, 1993
PubMed
Summary

Rectal amputation caused specific motor neuron damage in the Onufrowicz nucleus and sacral intermediolateral cell column. Findings support functional localization of sacral motor neuron pools for anorectal and urinary functions.

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Area of Science:

  • Neuroscience
  • Anatomy
  • Pathology

Background:

  • Sacral motor neuron pools innervate pelvic organs.
  • Functional localization within these pools is suggested by animal studies.

Purpose of the Study:

  • To investigate the neuropathological effects of rectal amputation on sacral motor neurons.
  • To correlate human findings with animal models of functional localization.

Main Methods:

  • Neuropathological examination of sacral spinal cord tissue.
  • Microscopic analysis of motor neurons in the Onufrowicz nucleus and sacral intermediolateral cell column.

Main Results:

  • Axonal reaction observed in dorsomedial Onufrowicz nucleus motor neurons; ventrolateral portion preserved.

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  • Localized chromatolysis in the ventral sacral intermediolateral cell column; lateral portion intact.
  • Findings align with animal studies indicating functional segregation of motor neuron pools.

    • Conclusions:

    • Human neuropathology after rectal amputation supports functional localization within sacral motor neuron pools.
    • Demonstrates specific vulnerability of dorsomedial Onufrowicz neurons and ventral intermediolateral column neurons to rectal amputation-related injury.
    • Reinforces the concept of distinct neural circuits for anorectal and vesico-urinary functions.