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Clinical studies on MFP/calcium containing abrasive

P F DePaola1

  • 1Department of Clinical Trials, Forsyth Dental Center, Boston, MA 02115.

International Dental Journal
|February 1, 1993
PubMed
Summary

Monofluorophosphate (MFP) combined with dicalcium dihydrate (dical) abrasive may enhance fluoride uptake and remineralization in dental caries. However, clinical trial results comparing MFP with dical versus calcium-free abrasives are inconclusive.

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Area of Science:

  • Dental materials science
  • Cariology
  • Fluoride chemistry

Background:

  • Monofluorophosphate (MFP) is a unique fluoride compound whose calcium salt exhibits notable solubility.
  • This solubility allows MFP to be incorporated into dentifrice formulations containing dicalcium dihydrate (dical) abrasive without compromising efficacy.
  • Previous studies indicate enhanced fluoride uptake in artificial enamel and dentin lesions from MFP formulations with dical compared to calcium-free alternatives.

Purpose of the Study:

  • To investigate the potential synergistic effect of dicalcium dihydrate (dical) abrasive on the efficacy of monofluorophosphate (MFP) in dentifrice formulations.
  • To evaluate whether the presence of calcium in MFP dentifrices enhances fluoride uptake and remineralization of artificial caries lesions.
  • To address the lack of direct comparative studies between MFP dentifrices with dical and non-calcium abrasive systems.

Main Methods:

  • Review of existing clinical trial data and in situ remineralization studies involving MFP dentifrices.
  • Analysis of fluoride and calcium levels in plaque following brushing with different MFP formulations.
  • Comparison of remineralization rates of artificial caries lesions in response to various dentifrice compositions.

Main Results:

  • MFP formulations containing dical abrasive demonstrated significantly greater fluoride uptake by artificial enamel and dentin lesions.
  • In situ studies showed increased fluoride and calcium levels in plaque after brushing with MFP/dical, correlating with enhanced remineralization of artificial caries lesions.
  • Overall clinical trial data comparing MFP/dical and calcium-free MFP formulations have not shown consistently superior results for the dical-containing agents.

Conclusions:

  • Dicalcium dihydrate (dical) may enhance the therapeutic benefits of monofluorophosphate (MFP) in dentifrice formulations, particularly in fluoride uptake and remineralization.
  • Despite promising findings in specific studies, comprehensive clinical data do not definitively establish the superiority of MFP/dical over calcium-free MFP dentifrices.
  • Further direct comparative studies are warranted to elucidate the precise role and efficacy of dical abrasive in MFP-based anti-caries dentifrices.

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