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Magnetic resonance imaging after arterial portography with manganese dipyridoxal diphosphate
R C Nelson1, J L Chezmar, G H Thompson
1Department of Radiology, Frederik Philips Magnetic Resonance Research Center, Emory University School of Medicine, Atlanta, Georgia 30322.
Rationale And Objectives:
The authors assess performing hepatic magnetic resonance imaging (MRI) after arterial portography with manganese dipyridoxal diphosphate (MnD-PDP), a hepatobiliary contrast agent, as an invasive but potentially highly sensitive means of focal lesion detection.
Methods:
Eight pigs underwent superior mesenteric artery catheterization and injection of 10 mumol/kg MnDPDP. Magnetic resonance imaging at 1.5 T (SE-140/10) was performed before, then at 15 and 30 minutes after injection. Seven or more days later, the same MRI protocol was performed after intravenous injection of 10 mumol/kg MnDPDP.
Results:
Fifteen minutes after intra-arterial injection, enhancement of the liver predominated (86 +/- 13%), followed by the renal cortex (44 +/- 14%), pancreas (26 +/- 9%), and spleen (14 +/- 9%). At 30 minutes, enhancement of renal cortex significantly increased (50 +/- 14%). There was no significant difference in enhancement of the liver, spleen, pancreas, or renal cortex when we compared intra-arterial and intravenous administration.
Conclusion:
After the injection of 10 mumol/kg MnDPDP into the superior mesenteric artery of pigs there is no significant difference in visceral organ enhancement compared to intravenous administration. The data suggests that the hepatocyte binding sites may be overwhelmed by this dose and/or injection rate of MnDPDP.
Insights
Arterial portography with manganese dipyridoxal diphosphate (MnDPDP) did not significantly enhance liver MRI visibility compared to intravenous administration in pigs. This suggests the dose may overwhelm hepatocyte binding sites for focal lesion detection.
Area of Science:
- Radiology
- Hepatobiliary Imaging
- Contrast Agents
Background:
- Hepatic magnetic resonance imaging (MRI) is crucial for focal lesion detection.
- Arterial portography with hepatobiliary contrast agents is explored for enhanced sensitivity.
- Manganese dipyridoxal diphosphate (MnDPDP) is a potential hepatobiliary contrast agent.
Purpose of the Study:
- To evaluate the efficacy of hepatic MRI after arterial portography with MnDPDP for focal lesion detection.
- To compare MnDPDP enhancement via intra-arterial versus intravenous administration.
- To assess the sensitivity of this invasive technique for lesion detection.
Main Methods:
- Eight pigs underwent superior mesenteric artery catheterization and MnDPDP injection.
- MRI was performed at 1.5 T before and after intra-arterial MnDPDP injection (15 and 30 minutes).
- The same MRI protocol was repeated after intravenous MnDPDP injection on a separate occasion.
Main Results:
- Fifteen minutes post-intra-arterial injection, liver enhancement was predominant (86%).
- Renal cortex, pancreas, and spleen showed significant enhancement at 15 and 30 minutes.
- No significant difference in organ enhancement was observed between intra-arterial and intravenous MnDPDP administration.
Conclusions:
- Intra-arterial MnDPDP administration in pigs did not yield significantly different visceral organ enhancement compared to intravenous administration.
- The study suggests that the tested dose and/or injection rate of MnDPDP may saturate hepatocyte binding sites.
- Further research may be needed to optimize MnDPDP administration for improved hepatic MRI sensitivity.
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