Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamic field shaping for stereotactic radiosurgery: a modeling study

L A Nedzi1, H M Kooy, E Alexander

  • 1Joint Center for Radiation Therapy, Brigham and Women's Hospital, Boston, MA.

International Journal of Radiation Oncology, Biology, Physics
|April 2, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

On repairing racial ruptures after racial microaggressions: A mixed methods study with Black graduate students.

Journal of counseling psychology·2026
Same author

Outcome and feasibility of radiotherapy bridging in large B-cell lymphoma patients receiving CD19 CAR T in the UK.

British journal of haematology·2024
Same author

Parents' priorities and preferences for treatment of children with ADHD: Qualitative inquiry in the MADDY study.

Child: care, health and development·2022
Same author

Implementation of apertures in a proton pencil-beam dose algorithm.

Biomedical physics & engineering express·2022
Same author

Ileal pouch-anal anastomosis in ulcerative colitis: outcomes, functional results, and quality of life in patients with more than 10-year follow-up.

International journal of colorectal disease·2020
Same author

Impact of setup and range uncertainties on TCP and NTCP following VMAT or IMPT of oropharyngeal cancer patients.

Physics in medicine and biology·2019

Dynamic field shaping devices offer significant advantages for stereotactic radiosurgery. Simple devices provide half the conformal benefit of an ideal multileaf collimator, improving treatment accuracy for many tumors.

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Neurosurgery

Background:

  • Stereotactic radiosurgery (SRS) utilizes precise radiation delivery for intracranial tumors.
  • Linear accelerators (LINACs) are common platforms for SRS.
  • Field shaping devices are crucial for optimizing dose distribution and minimizing off-target radiation exposure.

Purpose of the Study:

  • To evaluate the relative field shaping capabilities of various dynamic field shaping devices for SRS.
  • To compare the efficacy of different collimator designs, including multileaf collimators (MLCs), in conformal radiation therapy.
  • To assess the potential improvements in dose coverage and treatment volume ratio offered by advanced collimator technologies.

Main Methods:

  • Modeled five field shaping devices: fixed circular collimator, two/four independent parallel/rectangular jaws, and an "ideal" MLC.

Related Experiment Videos

  • Utilized data from 43 intracranial tumors treated with SRS.
  • Defined treatment volume ratio (target volume/treatment volume) to quantify field shaping efficiency.
  • Adjusted models to ensure minimum target isodose was 80% of the isocenter dose.
  • Main Results:

    • For single-isocenter treatments, all modeled devices except the fixed circular collimator showed improved Treatment Volume Ratio compared to actual patient treatments.
    • For multiple-isocenter treatments, two/four independent jaws and the "ideal" MLC demonstrated superior Treatment Volume Ratio compared to actual treatments.
    • Simple field shaping devices achieved approximately 50% of the conformal advantage of an "ideal" MLC.

    Conclusions:

    • Simple field shaping devices offer substantial conformal advantages over basic collimators.
    • Advanced jaw designs (two parallel, four rectangular, or four rotatable) can improve upon current LINAC technology for SRS.
    • Approximately 50% of radiosurgical tumors treated exhibit field shaping benefits that surpass inherent geometrical uncertainties in LINAC-based SRS.