Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparison of macrolide antibiotics

J D Williams1, A M Sefton

  • 1Department of Medical Microbiology, London Hospital Medical College, UK.

The Journal of Antimicrobial Chemotherapy
|March 1, 1993
PubMed
Summary

Newer macrolide antibiotics offer improved dosing schedules and varied in-vitro activity compared to erythromycin. Further clinical studies are needed to understand their complex pharmacology and efficacy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antimicrobial use and microbiological testing in district general hospital ICUs of the Veneto region of north-east Italy.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2016
Same author

Post-exposure prophylaxis of systemic anthrax in mice and treatment with fluoroquinolones.

The Journal of antimicrobial chemotherapy·2004
Same author

Comparative in-vitro activity of penicillin alone and combined with gentamicin against clinical isolates of Streptococcus pneumoniae with decreased susceptibility to penicillin.

International journal of antimicrobial agents·2002
Same author

The Great Pox that was...syphilis.

Journal of applied microbiology·2001
Same author

Multiple mutations modulate the function of dihydrofolate reductase in trimethoprim-resistant Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy·2001
Same author

The impact of resistance on the management of urinary tract infections.

International journal of antimicrobial agents·2000

Area of Science:

  • Pharmacology
  • Microbiology
  • Infectious Diseases

Background:

  • Macrolides have been clinically utilized since the 1950s.
  • Erythromycin, a first-generation macrolide, presents challenges in clinical application.
  • Recent advancements have introduced novel macrolides to address these limitations.

Purpose of the Study:

  • To review the in-vitro activity, pharmacology, and clinical implications of newer macrolide antibiotics.
  • To compare the efficacy and pharmacokinetic profiles of new macrolides against erythromycin.

Main Methods:

  • Comparative analysis of in-vitro antimicrobial activity.
  • Review of pharmacokinetic parameters, including tissue distribution and intracellular penetration.
  • Assessment of dosing frequency and potential impact on patient compliance.

Main Results:

  • Newer macrolides exhibit similar in-vitro activity to erythromycin, with notable exceptions.
  • Azithromycin demonstrates enhanced activity against Haemophilus influenzae and certain Gram-negative bacteria.
  • Clarithromycin shows superior in-vitro activity against Legionella spp. and Chlamydia pneumoniae.
  • Pharmacokinetic variations among macrolides present interpretive challenges.
  • Newer macrolides offer improved dosing regimens (once or twice daily), potentially increasing patient compliance.

Conclusions:

  • New macrolides possess distinct in-vitro activity profiles and pharmacokinetic properties.
  • Improved dosing convenience is a significant advantage of newer macrolide agents.
  • Further clinical efficacy studies are crucial for a comprehensive understanding of macrolide pharmacology and therapeutic value.

Related Experiment Videos