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Related Experiment Videos

Dirithromycin disc susceptibility tests: interpretative criteria and quality control parameters

A L Barry1, M A Pfaller, P C Fuchs

  • 1Clinical Microbiology Institute, Tualatin, Oregon 97062.

The Journal of Antimicrobial Chemotherapy
|March 1, 1993
PubMed
Summary

Dirithromycin and its metabolite showed similar in vitro activity, though less potent than erythromycin. New interpretive criteria were established for dirithromycin susceptibility testing in clinical laboratories.

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Area of Science:

  • Microbiology
  • Pharmacology

Background:

  • Dirithromycin is a macrolide antibiotic.
  • Its bioactive metabolite is erythromycylamine.
  • Erythromycin is a reference macrolide antibiotic.

Purpose of the Study:

  • Compare the in vitro activity of dirithromycin and erythromycylamine to erythromycin.
  • Establish interpretive criteria for dirithromycin susceptibility testing.
  • Define quality control limits for susceptibility tests.

Main Methods:

  • In vitro susceptibility testing against 450 bacterial isolates using disc diffusion and broth microdilution.
  • Comparison of dirithromycin, erythromycylamine, and erythromycin activity.
  • Two multi-laboratory studies for quality control limit definition.

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Main Results:

  • Dirithromycin and erythromycylamine exhibited similar in vitro activity, additive when combined.
  • Both were active against erythromycin-susceptible bacteria, but erythromycin was 2-4 times more potent.
  • Established interpretive criteria: susceptible zones ≥19 mm or MIC ≤2.0 mg/L; resistant zones ≤15 mm or MIC ≥8.0 mg/L.
  • Poor activity of dirithromycin against Haemophilus influenzae in the tested system.

Conclusions:

  • Dirithromycin and its metabolite possess in vitro activity, but are less potent than erythromycin.
  • Defined susceptibility testing criteria for dirithromycin are crucial for clinical application.
  • Further studies are needed to optimize testing for specific pathogens like H. influenzae.