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Related Experiment Videos

Hip and knee replacement in osteogenesis imperfecta

P J Papagelopoulos1, B F Morrey

  • 1Department of Orthopaedic Surgery, Mayo Clinic, Rochester, Minnesota 55905.

The Journal of Bone and Joint Surgery. American Volume
|April 1, 1993
PubMed
Summary

Total hip and knee arthroplasty in osteogenesis imperfecta patients provided significant pain relief and improved mobility. While generally successful, one patient experienced a rare complication of acetabular component protrusion.

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Area of Science:

  • Orthopedic Surgery
  • Rheumatology
  • Genetics

Background:

  • Osteogenesis imperfecta (OI) is a genetic disorder characterized by brittle bones, leading to frequent fractures and skeletal deformities.
  • Joint involvement and pain are common in OI, often necessitating surgical intervention.
  • Arthroplasty, particularly total hip and knee replacement, is considered for managing severe joint degeneration and pain in OI patients.

Purpose of the Study:

  • To evaluate the outcomes of total hip arthroplasty (THA) and total knee arthroplasty (TKA) in patients with osteogenesis imperfecta.
  • To assess the efficacy of arthroplasty in relieving pain and improving functional mobility in this patient population.
  • To identify any postoperative complications associated with joint replacement in OI patients.

Main Methods:

  • A retrospective review of six patients with osteogenesis imperfecta who underwent a total of five THAs and three TKAs between 1969 and 1990.
  • Patients were followed for a mean of 7 years after hip arthroplasty and 10 years after knee arthroplasty.
  • Outcomes assessed included pain relief, ambulation status, and postoperative complications.

Main Results:

  • All patients reported significant postoperative pain relief.
  • Postoperatively, all patients were able to ambulate, with one using a walker and two using a cane.
  • The sole complication noted was an intrapelvic protrusion of the acetabular component, occurring six years after a bipolar hip replacement.

Conclusions:

  • Total hip and knee arthroplasty can effectively alleviate pain and improve ambulation in patients with osteogenesis imperfecta.
  • While generally safe and effective, careful patient selection and long-term monitoring are crucial due to the potential for rare complications like acetabular protrusion.

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